Twenty-four-hour profiles of acylated and total ghrelin: relationship with glucose levels and impact of time of day and sleep.

@article{Spiegel2011TwentyfourhourPO,
  title={Twenty-four-hour profiles of acylated and total ghrelin: relationship with glucose levels and impact of time of day and sleep.},
  author={Karine Spiegel and Esra Tasali and Rachel Leproult and Neal H Scherberg and Eve Van Cauter},
  journal={The Journal of clinical endocrinology and metabolism},
  year={2011},
  volume={96 2},
  pages={486-93}
}
CONTEXT The acylation of ghrelin is essential for its stimulatory effects on GH release and appetite. Most of the physiology of ghrelin has been defined based on the assay of total ghrelin (TG), which mainly reflects levels of unacylated ghrelin. Whether levels of acylated ghrelin (AG) are influenced by circadian time and sleep and impact glucose regulation under physiologic conditions is not known. METHODS Blood was sampled at 10- to 30-min intervals for 24 h in 14 healthy young lean men… CONTINUE READING

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