Twenty-four hour plasma profile of sustained-release isosorbide mononitrate in healthy volunteers and in patients with chronic stable angina. Two open label trials.

Abstract

AIMS The plasma profile of a single dose of isosorbide mononitrate 25 mg (Elantan LA25) in healthy volunteers and in angina patients was examined. METHODS In volunteers and patients, blood samples for pharmacokinetics were obtained pre-dosing and at intervals for 24 h after dosing. RESULTS This formulation exhibited rapid absorption and plasma levels were maintained at > 100 ng ml-1 for up to 9 to 12 h. CONCLUSIONS A comparison of the pharmacokinetics of Elantan LA25 in volunteers and patients indicates that the profiles are similar.

Cite this paper

@article{Baxter1997TwentyfourHP, title={Twenty-four hour plasma profile of sustained-release isosorbide mononitrate in healthy volunteers and in patients with chronic stable angina. Two open label trials.}, author={Tanya Baxter and Carolyne Eadie}, journal={British journal of clinical pharmacology}, year={1997}, volume={43 3}, pages={333-5} }