Twenty-four-hour heart rate lowering with ivabradine in chronic heart failure: insights from the SHIFT Holter substudy.

@article{Bhm2015TwentyfourhourHR,
  title={Twenty-four-hour heart rate lowering with ivabradine in chronic heart failure: insights from the SHIFT Holter substudy.},
  author={Michael B{\"o}hm and Jeffrey S. Borer and John Camm and Ian Ford Ford and Suzanne M. Lloyd and Michel Komajda and Luigi T Tavazzi and Mario R Talajic and Mitja Lainscak and Jan-Christian Reil and Christian Ukena and Karl Swedberg},
  journal={European journal of heart failure},
  year={2015},
  volume={17 5},
  pages={518-26}
}
AIMS Analysis of 24-h Holter recordings was a pre-specified substudy of SHIFT (Systolic Heart Failure Treatment with the If Inhibitor Ivabradine Trial) for exploring the heart rhythm safety of ivabradine and to determine effects of ivabradine on 24-h, daytime, and night-time heart rate (HR) compared with resting office HR. METHODS AND RESULTS The 24-h Holter monitoring was performed at baseline and 8 months after randomization to ivabradine (n = 298) or matching placebo (n = 304) titrated… CONTINUE READING
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