Twenty bone mineral density loci identified by large-scale meta-analysis of genome-wide association studies

  title={Twenty bone mineral density loci identified by large-scale meta-analysis of genome-wide association studies},
  author={Fernando Rivadeneira and Unnur Styrkarsdottir and Karol Estrada and Bjarni V Halldorsson and Y H Hsu and J Brent Richards and M C Carola Zillikens and Fotini K. Kavvoura and Najaf Amin and Yurii S. Aulchenko and L. Adrienne Cupples and Panagiotis Deloukas and Serkalem Demissie and Elin Grundberg and Albert Hofman and Augustine Kong and David Karasik and Joyce B. J. van Meurs and Ben A. Oostra and Tomi Pastinen and Huibert A. P. Pols and Gunnar Th. Sigurdsson and Nicole Soranzo and Gudmar Thorleifsson and Unnur Thorsteinsdottir and Frances M. K. Williams and Scott G. Wilson and Yanhua Zhou and Stuart H. Ralston and Cornelia M van Duijn and Tim D. Spector and Douglas P Kiel and K{\'a}ri Stef{\'a}nsson and John P. A. Ioannidis and Andr{\'e} G. Uitterlinden},
  booktitle={Nature Genetics},
Bone mineral density (BMD) is a heritable complex trait used in the clinical diagnosis of osteoporosis and the assessment of fracture risk. We performed meta-analysis of five genome-wide association studies of femoral neck and lumbar spine BMD in 19,195 subjects of Northern European descent. We identified 20 BMD loci that reached genome-wide significance (GWS; P < 5 × 10−8), of which 13 map to regions not previously associated with this trait: 1p31.3 (GPR177), 2p21 (SPTBN1), 3p22 (CTNNB1), 4q21… CONTINUE READING
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