Twenty Years of the Alzheimer’s Disease Amyloid Hypothesis: A Genetic Perspective

@article{Tanzi2005TwentyYO,
  title={Twenty Years of the Alzheimer’s Disease Amyloid Hypothesis: A Genetic Perspective},
  author={R. Tanzi and L. Bertram},
  journal={Cell},
  year={2005},
  volume={120},
  pages={545-555}
}
From Alois Alzheimer's description of Auguste D.'s brain in 1907 to George Glenner's biochemical dissection of beta-amyloid in 1984, the "amyloid hypothesis" of Alzheimer's disease has continued to gain support over the past two decades, particularly from genetic studies. Here we assess the amyloid hypothesis based on both known and putative Alzheimer's disease genes. 
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