Twenty Years of the Alzheimer’s Disease Amyloid Hypothesis: A Genetic Perspective

@article{Tanzi2005TwentyYO,
  title={Twenty Years of the Alzheimer’s Disease Amyloid Hypothesis: A Genetic Perspective},
  author={R. Tanzi and L. Bertram},
  journal={Cell},
  year={2005},
  volume={120},
  pages={545-555}
}
From Alois Alzheimer's description of Auguste D.'s brain in 1907 to George Glenner's biochemical dissection of beta-amyloid in 1984, the "amyloid hypothesis" of Alzheimer's disease has continued to gain support over the past two decades, particularly from genetic studies. Here we assess the amyloid hypothesis based on both known and putative Alzheimer's disease genes. 
1,604 Citations
Giving Alzheimer's the Old One-Two
  • 6
A current view of Alzheimer's disease
  • 14
  • PDF
Beyond pathology: APP, brain development and Alzheimer's disease
  • 29
Pathophysiology of Alzheimer's disease.
  • 65
  • PDF
Thirty years of Alzheimer's disease genetics: the implications of systematic meta-analyses
  • 668
Amyloid imaging of alzheimer’s disease using pittsburgh compound B
  • K. Johnson
  • Psychology, Medicine
  • Current neurology and neuroscience reports
  • 2006
  • 16
Genetic Mouse Models of Alzheimer's Disease
  • 19
  • PDF
...
1
2
3
4
5
...

References

SHOWING 1-10 OF 198 REFERENCES
Alzheimer's disease: A firm base for drug development
  • 46
  • PDF
Alzheimer's disease and Down's syndrome: sharing of a unique cerebrovascular amyloid fibril protein.
  • 1,438
  • Highly Influential
The Amyloid Hypothesis of Alzheimer's Disease: Progress and Problems on the Road to Therapeutics
  • 11,035
  • PDF
Clearance of Alzheimer's Abeta peptide: the many roads to perdition.
  • 192
Clearing the Brain's Amyloid Cobwebs
  • 514
Clearance of Alzheimer's Aβ Peptide The Many Roads to Perdition
  • 391
Strategies for disease modification in Alzheimer's disease
  • M. Citron
  • Medicine
  • Nature Reviews Neuroscience
  • 2004
  • 433
Mutation of the Alzheimer's disease amyloid gene in hereditary cerebral hemorrhage, Dutch type.
  • 977
Mutation of the Alzheimer's disease amyloid gene in hereditary cerebral hemorrhage, Dutch type.
  • 550
Alzheimer's disease: one disorder, too many genes?
  • 203
  • PDF
...
1
2
3
4
5
...