Twenty-Seven Years of Phase III Trials for Patients with Extensive Disease Small-Cell Lung Cancer: Disappointing Results

@inproceedings{Oze2009TwentySevenYO,
  title={Twenty-Seven Years of Phase III Trials for Patients with Extensive Disease Small-Cell Lung Cancer: Disappointing Results},
  author={Isao Oze and Katsuyuki Hotta and Katsuyuki Kiura and Nobuaki Ochi and Nagio Takigawa and Yoshiro Fujiwara and Masahiro Tabata and Mitsune Tanimoto},
  booktitle={PloS one},
  year={2009}
}
BACKGROUND Few studies have formally assessed whether treatment outcomes have improved substantially over the years for patients with extensive disease small-cell lung cancer (ED-SCLC) enrolled in phase III trials. The objective of the current investigation was to determine the time trends in outcomes for the patients in those trials. METHODS AND FINDINGS We searched for trials that were reported between January 1981 and August 2008. Phase III randomized controlled trials were eligible if… CONTINUE READING