Tweak induces mammary epithelial branching morphogenesis

@article{Michaelson2005TweakIM,
  title={Tweak induces mammary epithelial branching morphogenesis},
  author={Jennifer S. Michaelson and Sandy Shan-Ying Cho and Beth Grifli ths Browning and Timothy S. Zheng and John M. Lincecum and Monica Z. Wang and Yen-Ming Hsu and Linda Burkly},
  journal={Oncogene},
  year={2005},
  volume={24},
  pages={2613-2624}
}
Members of the tumor necrosis factor (TNF) superfamily regulate cell survival and proliferation and have been implicated in cancer. Tweak (TNF-related weak inducer of apoptosis) has pleiotropic biological functions including proapoptotic, proangiogenic and proinflammatory activities. We explored a role for Tweak in mammary gland transformation using a three-dimensional model culture system. Tweak stimulates a branching morphogenic phenotype, similar to that induced by pro-oncogenic factors, in… CONTINUE READING

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