Turnover of resident microglia in the normal adult mouse brain

@article{Lawson1992TurnoverOR,
  title={Turnover of resident microglia in the normal adult mouse brain},
  author={L. J. Lawson and V Hugh Perry and Siamon Gordon},
  journal={Neuroscience},
  year={1992},
  volume={48},
  pages={405-415}
}
We undertook this study to determine whether the microglia, the resident macrophages of the central nervous system, turn over in the steady-state. The turnover of brain macrophages would lend support to the "Trojan Horse" hypothesis of central nervous system infection, since one origin of replacement cells is the circulating monocyte pool. We combined the immunohistochemical detection of F4/80, a specific macrophage marker, with [3H]thymidine incorporation and autoradiography in normal adult… Expand
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