Turnover of rat liver tyrosine transaminase: stabilization after inhibition of protein synthesis.

@article{Kenney1967TurnoverOR,
  title={Turnover of rat liver tyrosine transaminase: stabilization after inhibition of protein synthesis.},
  author={F. T. Kenney},
  journal={Science},
  year={1967},
  volume={156 3774},
  pages={525-8}
}
Turnover of the rat liver tyrosine transaminase in vivo was measured by a label and chase procedure under conditions where the amount of enzyme undergoes no change. Half-life of the (14)C-labeled enzyme in this basal condition was found to be 1.5 +/- 0.3 hours. Inhibitors of protein synthesis (cycloheximide or puromycin) do not appreciably influence the basal enzyme level over a 5-hour period, although these drugs will block hormonal induction of this enzyme. In pulse-labeling experiments… CONTINUE READING

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