Turnover of amyloid beta-protein in mouse brain and acute reduction of its level by phorbol ester.

@article{Savage1998TurnoverOA,
  title={Turnover of amyloid beta-protein in mouse brain and acute reduction of its level by phorbol ester.},
  author={Mary Josephine Savage and Stephen P Trusko and David S Howland and L R Pinsker and S Mistretta and Andrew G Reaume and Barry D. Greenberg and Robert A Siman and Richard W. Scott},
  journal={The Journal of neuroscience : the official journal of the Society for Neuroscience},
  year={1998},
  volume={18 5},
  pages={1743-52}
}
Fibrillar amyloid deposits are defining pathological lesions in Alzheimer's disease brain and are thought to mediate neuronal death. Amyloid is composed primarily of a 39-42 amino acid protein fragment of the amyloid precursor protein (APP), called amyloid beta-protein (Abeta). Because deposition of fibrillar amyloid in vitro has been shown to be highly dependent on Abeta concentration, reducing the proteolytic release of Abeta is an attractive, potentially therapeutic target. Here, the… CONTINUE READING

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Protein kinase C : structure , function , and regulation

  • A Newton
  • J Biol Chem
  • 1995
Highly Influential
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