Corpus ID: 30138784

Turnover and tissue sites of degradation of glucosylated low density lipoprotein in normal and immunized rabbits.

@article{Wiklund1987TurnoverAT,
  title={Turnover and tissue sites of degradation of glucosylated low density lipoprotein in normal and immunized rabbits.},
  author={Olov Wiklund and Joseph L. Witztum and Thomas E. Carew and Ray C. Pittman and Richard L. Elam and Daniel I Steinberg},
  journal={Journal of lipid research},
  year={1987},
  volume={28 9},
  pages={
          1098-109
        }
}
Immunological mechanisms have been implicated in the atherogenic process since immunoglobulins are frequently found in the atherosclerotic aorta. We have previously shown that modifications of homologous low density lipoproteins (LDL) make it immunogenic. In particular we have demonstrated that immunization with homologous nonenzymatically glucosylated LDL (glcLDL) results in the generation of antibodies specific to the derivatized lysine residue, and that such antibodies do not react with… Expand
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