Turning the Light On in the Phenotypic Drug Discovery Black Box.


In this issue, Drawnel et al. (2017) introduce the concept of a "molecular phenotype" and demonstrate how "big data" coming from gene expression profiling, combined with signaling pathway information, small-molecule chemical information, preclinical animal models, and clinical samples can empower phenotypic discovery at several critical levels. 
DOI: 10.1016/j.chembiol.2017.05.005


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