Turning terminally differentiated skeletal muscle cells into regenerative progenitors

  title={Turning terminally differentiated skeletal muscle cells into regenerative progenitors},
  author={Heng Wang and Sara L{\"o}{\"o}f and Paula Borg and Gustavo A. Nader and Helen M. Blau and Andr{\'a}s Simon},
  booktitle={Nature communications},
The ability to repeatedly regenerate limbs during the entire lifespan of an animal is restricted to certain salamander species among vertebrates. This ability involves dedifferentiation of post-mitotic cells into progenitors that in turn form new structures. A long-term enigma has been how injury leads to dedifferentiation. Here we show that skeletal muscle dedifferentiation during newt limb regeneration depends on a programmed cell death response by myofibres. We find that programmed cell… CONTINUE READING
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Limb regeneration.

Wiley interdisciplinary reviews. Developmental biology • 2013

Regulation of p53 is critical for vertebrate limb regeneration.

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