Turning signals on and off: GLUT4 traffic in the insulin-signaling highway.

  title={Turning signals on and off: GLUT4 traffic in the insulin-signaling highway.},
  author={Farah S L Thong and Chandrasagar B. Dugani and Amira Klip},
Insulin stimulation of glucose uptake into skeletal muscle and adipose tissues is achieved by accelerating glucose transporter GLUT4 exocytosis from intracellular compartments to the plasma membrane and minimally reducing its endocytosis. The round trip of GLUT4 is intricately regulated by diverse signaling molecules impinging on specific compartments. Here we highlight the key molecular signals that are turned on and off by insulin to accomplish this task. 
Recent Discussions
This paper has been referenced on Twitter 7 times over the past 90 days. VIEW TWEETS

From This Paper

Figures, tables, and topics from this paper.
80 Citations
158 References
Similar Papers


Publications citing this paper.
Showing 1-10 of 80 extracted citations


Publications referenced by this paper.
Showing 1-10 of 158 references

Positive and negative regulation of insulin signaling through IRS-1 phosphorylation

  • P Gual, Y Marchand-Brustel, JF. Tanti
  • Biochimie 87:
  • 2005
Highly Influential
4 Excerpts

To be or not to be: regulation of the intrinsic activity of GLUT4

  • CN Antonescu, FSL Thong, W Niu, E Karnieli, A. Klip
  • Curr Med Chem Immunol Endo Metab Agents
  • 2005
Highly Influential
7 Excerpts

Similar Papers

Loading similar papers…