Turning of Retinal Growth Cones in a Netrin-1 Gradient Mediated by the Netrin Receptor DCC

  title={Turning of Retinal Growth Cones in a Netrin-1 Gradient Mediated by the Netrin Receptor DCC},
  author={Jos{\'e} R. de la Torr{\'e} and Veit H. H{\"o}pker and Guoli Ming and Mu-Ming Poo and Marc Tessier-Lavigne and Ali Hemmati-Brivanlou and Christine E Holt},
Netrin-1 promotes outgrowth of axons in vitro through the receptor Deleted in Colorectal Cancer (DCC) and elicits turning of axons within embryonic explants when presented as a point source. It is not known whether netrin-1 alone can elicit turning nor whether DCC mediates the turning response. We show that Xenopus retinal ganglion cell growth cones orient rapidly toward a pipette ejecting netrin-1, an effect blocked by antibodies to DCC. In vitro, netrin-1 induces a complex growth cone… CONTINUE READING

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