Turning mesoderm into blood: the formation of hematopoietic stem cells during embryogenesis.

@article{Davidson2000TurningMI,
  title={Turning mesoderm into blood: the formation of hematopoietic stem cells during embryogenesis.},
  author={Alan J. W. Davidson and Leonard I. Zon},
  journal={Current topics in developmental biology},
  year={2000},
  volume={50},
  pages={45-60}
}
The formation of hematopoietic stem cells during development occurs by a multistep process that begins with the induction of ventral mesoderm. This mesoderm is patterned during gastrulation by a bone morphogenetic protein (BMP) signaling pathway that is mediated, at least in part, by members of the Mix and Vent families of homeobox transcription factors. Following gastrulation, a subset of ventral mesoderm is specified to become hematopoietic stem cells. Key determinants of hematopoietic fate… CONTINUE READING

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