Turning cancer stem cells inside out: an exploration of glioma stem cell signaling pathways.

@article{Li2009TurningCS,
  title={Turning cancer stem cells inside out: an exploration of glioma stem cell signaling pathways.},
  author={Zhizhong Li and Hui Wang and Christine E. Eyler and Anita B. Hjelmeland and Jeremy Rich},
  journal={The Journal of biological chemistry},
  year={2009},
  volume={284 25},
  pages={16705-9}
}
Tumors are complex collections of heterogeneous cells with recruited vasculature, inflammatory cells, and stromal elements. Neoplastic cells frequently display a hierarchy in differentiation status. Recent studies suggest that brain tumors have a limited population of neoplastic cells called cancer stem cells with the capacity for sustained self-renewal and tumor propagation. Brain tumor stem cells contribute to therapeutic resistance and tumor angiogenesis. In this minireview, we summarize… CONTINUE READING

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