Turning a monocovalent flavoprotein into a bicovalent flavoprotein by structure-inspired mutagenesis.

@article{Kopacz2014TurningAM,
  title={Turning a monocovalent flavoprotein into a bicovalent flavoprotein by structure-inspired mutagenesis.},
  author={Malgorzata M Kopacz and Marco W Fraaije},
  journal={Bioorganic & medicinal chemistry},
  year={2014},
  volume={22 20},
  pages={5621-7}
}
A recently discovered class of bicovalent flavoproteins is an interesting group of enzymes because of their unusual cofactor binding mode, their open active sites and the bulky substrates they can accept. Through a sequence comparison study we have identified a conserved sequence region in bicovalent flavoproteins that is different from monocovalent… CONTINUE READING