Turning Stem Cells Bad: Generation of Clinically Relevant Models of Human Acute Myeloid Leukemia through Gene Delivery- or Genome Editing-Based Approaches

@inproceedings{Mesuraca2018TurningSC,
  title={Turning Stem Cells Bad: Generation of Clinically Relevant Models of Human Acute Myeloid Leukemia through Gene Delivery- or Genome Editing-Based Approaches},
  author={Maria Mesuraca and Nicola Amodio and Emanuela Chiarella and Stefania Scicchitano and Annamaria Aloisio and Bruna Codispoti and Valeria Lucchino and Ylenia Montalcini and Heather M Bond and Giovanni Morrone},
  booktitle={Molecules},
  year={2018}
}
Acute myeloid leukemia (AML), the most common acute leukemia in the adult, is believed to arise as a consequence of multiple molecular events that confer on primitive hematopoietic progenitors unlimited self-renewal potential and cause defective differentiation. A number of genetic aberrations, among which a variety of gene fusions, have been implicated in the development of a transformed phenotype through the generation of dysfunctional molecules that disrupt key regulatory mechanisms… CONTINUE READING
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