Turning CALM into excitement: AP180 and CALM in endocytosis and disease.

  title={Turning CALM into excitement: AP180 and CALM in endocytosis and disease.},
  author={Tanja Maritzen and Seong Joo Koo and Volker Haucke},
  journal={Biology of the cell},
  volume={104 10},
Dynamic flux of membrane between intracellular compartments is a key feature of all eukaryotic cells. Soluble N-ethylmaleimide-sensitive factor attachment protein receptors (SNAREs) play a crucial role in membrane dynamics by facilitating membrane fusion, for example at synapses where small synaptic vesicles (SVs) undergo activity-regulated neuroexocytosis, followed by the endocytic re-cycling of SV proteins and lipids. Recent work shows that the assembly protein 180 (AP180) N-terminal homology… CONTINUE READING
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