Turn me on: regulating HIF transcriptional activity

@article{Lisy2008TurnMO,
  title={Turn me on: regulating HIF transcriptional activity},
  author={K. Lisy and D. Peet},
  journal={Cell Death and Differentiation},
  year={2008},
  volume={15},
  pages={642-649}
}
  • K. Lisy, D. Peet
  • Published 2008
  • Biology, Medicine
  • Cell Death and Differentiation
The hypoxia-inducible factors (HIFs) are critical for cellular adaptation to limiting oxygen and regulate a wide array of genes when cued by cellular oxygen-sensing mechanisms. HIF is able to direct transcription from either of two transactivation domains, each of which is regulated by distinct mechanisms. The oxygen-dependent asparaginyl hydroxylase factor-inhibiting HIF-1α (FIH-1) is a key regulator of the HIF C-terminal transactivation domain, and provides a direct link between oxygen… Expand
Hypoxia-inducible factors: post-translational crosstalk of signaling pathways.
Regulation of gene expression by hypoxia.
Mechanisms of regulation of transcription factor HIF under hypoxia
Epigenetics: New Questions on the Response to Hypoxia
The role of hypoxia in development of the Mammalian embryo.
Studies on HIF hydroxylases
...
1
2
3
4
5
...

References

SHOWING 1-10 OF 77 REFERENCES
The hypoxia-inducible factors: key transcriptional regulators of hypoxic responses
The Transcriptional Activation Function of the HIF-like Factor Requires Phosphorylation at a Conserved Threonine*
Signalling hypoxia by HIF hydroxylases.
The role of iron and 2-oxoglutarate oxygenases in signalling.
Activation of Hypoxia-inducible Transcription Factor Depends Primarily upon Redox-sensitive Stabilization of Its α Subunit*
Activity of hypoxia-inducible factor 2alpha is regulated by association with the NF-kappaB essential modulator.
MAPK Signaling Up-regulates the Activity of Hypoxia-inducible Factors by Its Effects on p300*
...
1
2
3
4
5
...