Turing instability mediated by voltage and calcium diffusion in paced cardiac cells.

@article{Shiferaw2006TuringIM,
  title={Turing instability mediated by voltage and calcium diffusion in paced cardiac cells.},
  author={Yohannes Shiferaw and Alain Karma},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={2006},
  volume={103 15},
  pages={5670-5}
}
In cardiac cells, the coupling between the voltage across the cell membrane (V(m)) and the release of calcium (Ca) from intracellular stores is a crucial ingredient of heart function. Under abnormal conditions and/or rapid pacing, both the action potential duration and the peak Ca concentration in the cell can exhibit well known period-doubling oscillations referred to as "alternans," which have been linked to sudden cardiac death. Fast diffusion of V(m) keeps action potential duration… CONTINUE READING

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