Turcot Syndrome: A Synchronous Clinical Presentation of Glioblastoma Multiforme and Adenocarcinoma of the Colon

@inproceedings{Dipro2012TurcotSA,
  title={Turcot Syndrome: A Synchronous Clinical Presentation of Glioblastoma Multiforme and Adenocarcinoma of the Colon},
  author={Sabiq Anjum Dipro and Faisal A J Al-Otaibi and Adel H Alzahrani and Anwar Ulhaq and Essam Al Shail},
  booktitle={Case reports in oncological medicine},
  year={2012}
}
Turcot syndrome (TS) is a rare hereditary disorder clinically characterized by the occurrence of primary tumors of the colon and the central nervous system (CNS). Here we present the case of an 11-year-old boy with a synchronous clinical presentation of both glioblastoma multiforme (GBM) and colonic adenocarcinoma. A molecular genetic study revealed microsatellite instability in the DNA mismatch repair (MMR) gene. This patient ultimately survived for 13 months after clinical presentation. Based… CONTINUE READING