Turbocharging vaccines: emerging adjuvants for dendritic cell based therapeutic cancer vaccines.

@article{Saxena2017TurbochargingVE,
  title={Turbocharging vaccines: emerging adjuvants for dendritic cell based therapeutic cancer vaccines.},
  author={Mansi Saxena and Nina Bhardwaj},
  journal={Current opinion in immunology},
  year={2017},
  volume={47},
  pages={
          35-43
        }
}
Development of therapeutic cancer vaccines has been hindered by the many pro-tumorigenic mechanisms at play in cancer patients that serve to suppress both antigen presenting cells and T cells. In face of these obstacles, cancer vaccines are most likely to promote anti-tumorigenic immune responses only when formulated with strong adjuvants, and in combination with new immune interventions designed to reverse immune suppression and exhaustion of T cells in the tumor microenvironment. Dendritic… CONTINUE READING
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