Tuning three-dimensional collagen matrix stiffness independently of collagen concentration modulates endothelial cell behavior.

Abstract

Numerous studies have described the effects of matrix stiffening on cell behavior using two-dimensional synthetic surfaces; however, less is known about the effects of matrix stiffening on cells embedded in three-dimensional in vivo-like matrices. A primary limitation in investigating the effects of matrix stiffness in three dimensions is the lack of… (More)
DOI: 10.1016/j.actbio.2012.08.007

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