Tuning the responsiveness of a sensory receptor via covalent modification.

@article{Dunten1991TuningTR,
  title={Tuning the responsiveness of a sensory receptor via covalent modification.},
  author={Pete Dunten and Daniel E. Koshland},
  journal={The Journal of biological chemistry},
  year={1991},
  volume={266 3},
  pages={1491-6}
}
Down-regulation or adaptation of receptors is an essential part of the chemotaxis mechanism to sense gradients. Using localized mutagenesis it is shown that the covalent modification of the receptors makes a slight change in the binding constant (factor of 2) which is far too small to explain the adaptation. The modification does, however, alter the signaling dramatically, an increasing tumbling signal being correlated with increased covalent modification. Responses in the two extreme cases… CONTINUE READING

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