Tuning the Ion Selectivity of Two-Pore Channels

@inproceedings{Guo2017TuningTI,
  title={Tuning the Ion Selectivity of Two-Pore Channels},
  author={Jiangtao Guo and Weizhong Zeng and Youxing Jiang},
  year={2017}
}
Organellar two-pore channels (TPCs) contain two copies of a Shaker-like six-transmembrane (6-TM) domain in each subunit and are ubiquitously expressed in plants and animals. Interestingly, plant and animal TPCs share high sequence similarity in the filter region yet exhibit drastically different ion selectivity. Plant TPC1 functions as a non-selective, cation channel on the vacuole membrane, while mammalian TPC channels have been shown to be endo/lysosomal Na+-selective or Ca2+-release channels… CONTINUE READING

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