Tuning of mitochondrial pathways by muscle work: from triggers to sensors and expression signatures.

@article{Flck2009TuningOM,
  title={Tuning of mitochondrial pathways by muscle work: from triggers to sensors and expression signatures.},
  author={Martin Fl{\"u}ck},
  journal={Applied physiology, nutrition, and metabolism = Physiologie appliquee, nutrition et metabolisme},
  year={2009},
  volume={34 3},
  pages={447-53}
}
Performance of striated muscle relies on the nerve-driven activation of the sarcomeric motor and coupled energy supply lines. This biological engine is unique; its mechanical and metabolic characteristics are not fixed, but are tailored by functional demand with exercise. This remodelling is specific for the imposed muscle stimulus. This is illustrated by the increase in local oxidative capacity with highly repetitive endurance training vs. the preferential initiation of sarcomerogenesis with… CONTINUE READING

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