Tuning of macrophage responses by Stat3-inducing cytokines: molecular mechanisms and consequences in infection.

@article{Lang2005TuningOM,
  title={Tuning of macrophage responses by Stat3-inducing cytokines: molecular mechanisms and consequences in infection.},
  author={Roland Lang},
  journal={Immunobiology},
  year={2005},
  volume={210 2-4},
  pages={63-76}
}
A successful response to pathogen challenge requires that a balance is achieved between the induction of efficient anti-microbial effector mechanisms and the avoidance of detrimental tissue damage. While the Toll-like receptor (TLR) system is innate immunity's sensor of infectious danger, macrophages receive activating as well as inhibitory signals via the Jak-Stat pathway. IFNgamma is key to the control of infection particularly with intracellular pathogens and depends on functional Stat1… CONTINUE READING