Tuning of innate immunity and polarized responses by decoy receptors.

  title={Tuning of innate immunity and polarized responses by decoy receptors.},
  author={Alberto Mantovani and Raffaella Bonecchi and Fernando Oneissi Martinez and Emanuela Galliera and Patrick Perrier and Paola Allavena and Massimo Locati},
  journal={International archives of allergy and immunology},
  volume={132 2},
After the identification of the interleukin (IL)-1 type II receptor as the prototype, decoy receptors have been identified for a number of members of the IL-1/IL-18, TNF, IL-10 and IL-13 receptor families. Moreover, the silent receptor D6 is a promiscuous decoy and scavenger receptor of inflammatory chemokines. The IL-1 decoy receptor is regulated by pro- and anti-inflammatory signals and its levels may serve as a readout of the activation of anti-inflammatory pathways, for instance by… CONTINUE READING

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