Tuning of activation thresholds explains flexibility in the selection and development of T cells in the thymus.

Abstract

Immature CD4+ CD8+ thymocytes expressing T-cell antigen receptors (TCR) are selected by TCR-mediated recognition of peptides associated with major histocompatibility complex molecules on thymic stromal cells. Selection ensures reactivity of the mature cells to foreign antigens and tolerance to self. Although much has been learned about the factors that… (More)

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@article{Grossman1996TuningOA, title={Tuning of activation thresholds explains flexibility in the selection and development of T cells in the thymus.}, author={Z. Grossman and A. Singer}, journal={Proceedings of the National Academy of Sciences of the United States of America}, year={1996}, volume={93 25}, pages={14747-52} }