Tuning exocytosis for speed: fast and slow modes.

  title={Tuning exocytosis for speed: fast and slow modes.},
  author={Thomas F J Martin},
  journal={Biochimica et biophysica acta},
  volume={1641 2-3},
Exocytic fusion reactions triggered by Ca(2+) are widespread in neural, endocrine, exocrine, hemapoetic and perhaps all cell types. These processes exhibit tremendous variation in latencies to fusion following a Ca(2+) rise and in rates of fusion. We review reported differences for synaptic vesicle (SV) and dense-core vesicle (DCV) exocytosis and attempt to identify key features in the molecular mechanisms of docking, priming and fusion of SVs and DCVs that may account for differences in speed. 

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