Tuning cell differentiation patterns and single cell dynamics by regulating proteins' functionalities in a toggle switch.

@article{Dai2009TuningCD,
  title={Tuning cell differentiation patterns and single cell dynamics by regulating proteins' functionalities in a toggle switch.},
  author={Xiaofeng Dai and Shannon Healy and Olli P. Yli-Harja and Andre S. Ribeiro},
  journal={Journal of theoretical biology},
  year={2009},
  volume={261 3},
  pages={441-8}
}
We investigate how the regulation of protein multi-functionalities affect the dynamics of a stochastic model of a toggle switch and the differentiation pattern of cell population regulated by the switch. We study the effects of loss of functionality in DNA-binding and repression and the involvement in differentiation pathway choice. First is shown how the patterns of cell differentiation differ, when each of these functionalities is fully non-functional. Next, tuning the fraction of non… CONTINUE READING