Tuning T Cell Activation: The Function of CD6 At the Immunological Synapse and in T Cell Responses.

@article{Santos2016TuningTC,
  title={Tuning T Cell Activation: The Function of CD6 At the Immunological Synapse and in T Cell Responses.},
  author={Rita Melo Franco Santos and Liliana Oliveira and Alexandre M Carmo},
  journal={Current drug targets},
  year={2016},
  volume={17 6},
  pages={
          630-9
        }
}
CD6 immunotherapy to treat psoriasis and rheumatoid arthritis has reached the clinical trial stage with apparent success, and targeting CD6 with mAbs is being used in several animal models of autoimmunity and neuroinflammation with promising indications. However, the mode of action of the therapeutic CD6 mAbs is far from being understood, reflecting the uncertainties and controversy surrounding the mechanistic and biological functions of CD6. Initially regarded as a co-stimulatory receptor of T… CONTINUE READING

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