Tuning Sensitivity of CAR to EGFR Density Limits Recognition of Normal Tissue While Maintaining Potent Antitumor Activity.

@article{Caruso2015TuningSO,
  title={Tuning Sensitivity of CAR to EGFR Density Limits Recognition of Normal Tissue While Maintaining Potent Antitumor Activity.},
  author={Hillary G Caruso and Lenka V. Hurton and Amer M. Najjar and David Rushworth and Sonny A Ang and Simon Olivares and Tiejuan Mi and Kirsten C. Switzer and Harjeet Singh and Helen M Huls and Amanda J Lee and Amy Heimberger and Richard E. Champlin and Laurence J. N. Cooper},
  journal={Cancer research},
  year={2015},
  volume={75 17},
  pages={3505-18}
}
Many tumors overexpress tumor-associated antigens relative to normal tissue, such as EGFR. This limits targeting by human T cells modified to express chimeric antigen receptors (CAR) due to potential for deleterious recognition of normal cells. We sought to generate CAR(+) T cells capable of distinguishing malignant from normal cells based on the disparate density of EGFR expression by generating two CARs from monoclonal antibodies that differ in affinity. T cells with low-affinity nimotuzumab… CONTINUE READING
Recent Discussions
This paper has been referenced on Twitter 16 times over the past 90 days. VIEW TWEETS

Citations

Publications citing this paper.
Showing 1-10 of 60 extracted citations

References

Publications referenced by this paper.
Showing 1-10 of 51 references

Similar Papers

Loading similar papers…