Tuning HP1α chromodomain selectivity for di- and trimethyllysine.

@article{Eisert2011TuningHC,
  title={Tuning HP1α chromodomain selectivity for di- and trimethyllysine.},
  author={Robyn J. Eisert and Marcey L. Waters},
  journal={Chembiochem : a European journal of chemical biology},
  year={2011},
  volume={12 18},
  pages={2786-90}
}
Histone lysine methylation is a critical marker for controlling gene expression. The position and extent of methylation (mono-, di-, or tri-) controls the binding of effector proteins that determine whether the associated DNA is expressed or not. Dysregulation of histone protein methylation has been associated with a number of types of cancer, and development of inhibitors for the effector proteins is becoming an active area of research. For this reason, understanding the mechanism by which… CONTINUE READING

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