Tunicamycin-resistant Leishmania mexicana amazonensis: expression of virulence associated with an increased activity of N-acetylglucosaminyltransferase and amplification of its presumptive gene.

@article{Kink1987TunicamycinresistantLM,
  title={Tunicamycin-resistant Leishmania mexicana amazonensis: expression of virulence associated with an increased activity of N-acetylglucosaminyltransferase and amplification of its presumptive gene.},
  author={John Alan Kink and Kwang Poo Chang},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={1987},
  volume={84 5},
  pages={1253-7}
}
Tunicamycin at 10 micrograms/ml inhibits the growth and infectivity of the parasitic protozoan Leishmania mexicana amazonensis. Tunicamycin-resistant variants of this parasite were produced by gradual acclimatization of cells to increasing concentrations of the drug up to 80 micrograms/ml and a single-step selection of ethyl methanesulfonate-pretreated or differentiating leishmanias with the drug at 10 micrograms/ml. Prolonged exposure to the drug increases stability of drug resistance of those… CONTINUE READING

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Gene amplification in Leishmania.

Annual review of microbiology • 1991
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Highly Influenced

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Gene Amplification (Cold Spring Harbor Laboratory, Cold Spring Harbor, NY)

L. Rovis, S. Dube
Proc. Nati. Acad. Sci. USA • 1982

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