Tunicamycin and brefeldin a induce in plant cells a programmed cell death showing apoptotic features

@article{Crosti2001TunicamycinAB,
  title={Tunicamycin and brefeldin a induce in plant cells a programmed cell death showing apoptotic features},
  author={Paolo Crosti and Massimo Malerba and Renato Bianchetti},
  journal={Protoplasma},
  year={2001},
  volume={216},
  pages={31-38}
}
The recent identification ofDAD (defender against apoptotic death) gene in plants suggests that the N-linked glycosylation of proteins could be an important control point of plant programmed cell death. In this paper we describe the effects of Tunicamycin, an inhibitor of N-linked protein glycosylation, and Brefeldin A, an inhibitor of protein trafficking from the Golgi apparatus, on sycamore (Acer pseudoplatanus L.) cell cultures. These two chemicals proved able to induce a strong acceleration… CONTINUE READING

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