Tunica media changes in the spontaneously hypertensive rat (SHR).

@article{Hadjiisky1987TunicaMC,
  title={Tunica media changes in the spontaneously hypertensive rat (SHR).},
  author={Pierre Hadjiisky and Nicole Peyri and Yves Grosgogeat},
  journal={Atherosclerosis},
  year={1987},
  volume={65 1-2},
  pages={
          125-37
        }
}
The histological, ultrastructural, morphometrical and histochemical aspects of the arterial media were studied in young and aged SHR, and compared to normotensive Wistar Kyoto rats. The diffuse thickening was the most characteristic feature of the hypertensive media. It seems due to three processes: Early generalized hypertrophy of smooth muscle cells (smc); connective matrix neogenesis and smc proliferation, more evident in peripheral vasculature. The present paper discusses the following… CONTINUE READING
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