Tungsten exposure causes a selective loss of histone demethylase protein.

@article{LaulichtGlick2017TungstenEC,
  title={Tungsten exposure causes a selective loss of histone demethylase protein.},
  author={Freda Laulicht-Glick and Feng Wu and Xiaoru Zhang and Ashley T. Jordan and Jason Brocato and Thomas Kluz and Hong Sun and Max Costa},
  journal={Molecular carcinogenesis},
  year={2017},
  volume={56 7},
  pages={
          1778-1788
        }
}
In the course of our investigations into the toxicity of tungstate, we discovered that cellular exposure resulted in the loss of the histone demethylase protein. We specifically investigated the loss of two histone demethylase dioxygenases, JARID1A and JMJD1A. Both of these proteins were degraded in the presence of tungstate and this resulted in increased global levels of H3K4me3 and H3K9me2, the substrates of JARID1A and JMJD1A, respectively. Treatment with MG132 completely inhibited the loss… CONTINUE READING
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