Tunable reagents for multi-functional bioconjugation: reversible or permanent chemical modification of proteins and peptides by control of maleimide hydrolysis† †Electronic supplementary information (ESI) available: Full experimental details and characterisation. See DOI: 10.1039/c1cc11114k Click he

@inproceedings{Ryan2011TunableRF,
  title={Tunable reagents for multi-functional bioconjugation: reversible or permanent chemical modification of proteins and peptides by control of maleimide hydrolysis†
†Electronic supplementary information (ESI) available: Full experimental details and characterisation. See DOI: 10.1039/c1cc11114k
Click he},
  author={Chris P. Ryan and Mark E. B. Smith and Felix F. Schumacher and Dina Grohmann and Danai Papaioannou and Gabriel Waksman and Finn Werner and James R. Baker and Stephen Caddick},
  booktitle={Chemical communications},
  year={2011}
}
Controlling maleimide hydrolysis allows the modular construction of bromomaleimide-mediated bioconjugates which are either stable or cleavable in an aqueous, thiol-mediated reducing environment. The application of this methodology to reversible protein biotinylation, the irreversible labeling of peptide disulfide bonds and the assembly of stable, fluorescein-labelled glycoprotein mimics is described. 
14 Citations
1 References
Similar Papers

Citations

Publications citing this paper.
Showing 1-10 of 14 extracted citations

References

Publications referenced by this paper.

Chemical Reagents for Protein Modification

  • R. L. Lundblad
  • 2005

Similar Papers

Loading similar papers…