Tunable oscillations in the Purkinje neuron.

  title={Tunable oscillations in the Purkinje neuron.},
  author={Ze’ev R. Abrams and Ajithkumar Warrier and Yuan Wang and Dirk Trauner and Xiang Zhang},
  journal={Physical review. E, Statistical, nonlinear, and soft matter physics},
  volume={85 4 Pt 1},
In this paper, we experimentally study the dynamics of slow oscillations in Purkinje neurons in vitro, and derive a strong association with a forced parametric oscillator model. We observed the precise rhythmicity of these oscillations in Purkinje neurons, as well as a dynamic tunability of this oscillation using a photoswitchable compound. We found that this slow oscillation can be induced in every Purkinje neuron measured, having periods ranging between 10 and 25 s. Starting from a Hodgkin… 

Figures from this paper

Theta-Frequency Resonance at the Cerebellum Input Stage Improves Spike Timing on the Millisecond Time-Scale

It is shown that, at the cerebellum input stage, the granular layer (GRL) generates its maximum response at 5–7 Hz both in vivo following tactile sensory stimulation of the whisker pad and in acute slices following mossy fiber bundle stimulation.

Temporal integration and 1/f power scaling in a circuit model of cerebellar interneurons.

Stellate and basket cells in cerebellar cortex, and interneuron circuits in general, may not only provide fast inhibition to principal cells but also act as temporal integrators that build a very short-term memory.

Power Spectral Density Analysis of Purkinje Cell Tonic and Burst Firing Patterns From a Rat Model of Ataxia and Riluzole Treated

Spectral analysis of PCs firing in control, 3-acetylpyridine, neurotoxin agent, treated alone and riluzole plus 3-AP treated were investigated to determine changes in the firing properties and alterations in the power spectral density were found.

Photoswitchable Ion Channels and Receptors

The design, operation, and applications of the available photoswitches, with special emphasis on ligand- and voltage-gated channels, are described.



Cellular and network mechanisms of rhythmic recurrent activity in neocortex

The results demonstrate that the cerebral cortex generates an ‘up’ or depolarized state through recurrent excitation that is regulated by inhibitory networks, thereby allowing local cortical circuits to enter into temporarily activated and self-maintained excitatory states.

Bistability of cerebellar Purkinje cells modulated by sensory stimulation

It is demonstrated that rat and guinea pig cerebellar Purkinje cells in vivo show bistability of membrane potential and spike output on the time scale of seconds and the transition between membrane potential states can be bidirectionally triggered by the same brief current pulses.

Firing dynamics of cerebellar purkinje cells.

Knowledge of intrinsic neuronal firing dynamics is a critical first step to establishing an accurate biophysical model of any neuron. In this study we examined cerebellar Purkinje cells to determine

Calcium, Synaptic Plasticity and Intrinsic Homeostasis in Purkinje Neuron Models

It is concluded that calcium is unlikely to be the sole activity-sensor in this cell but that there is a strong relationship between activity homeostasis and synaptic plasticity.

Pausing Purkinje Cells in the Cerebellum of the Awake Cat

Proof for the existence of long pauses in the PC SS activity that probably reflect underlying bistability is presented, the first in-depth analysis of these pauses are provided and transitions in and out ofThese pauses are related to CS firing in the awake and behaving animal.

New dynamics in cerebellar Purkinje cells: torus canards.

It is proposed that the cerebellar Purkinje cell system exhibits a dynamical phenomenon new to realistic, biophysical applications: torus canards.

Purkinje cells in awake behaving animals operate at the upstate membrane potential

To confirm the occurrence of bistability in Purkinje cells, whole-cell patch recordings in vivo in mice under isoflurane or ketamine/xylazine anesthesia are performed.

Neuronal Oscillations in Cortical Networks

Recent findings indicate that network oscillations bias input selection, temporally link neurons into assemblies, and facilitate synaptic plasticity, mechanisms that cooperatively support temporal representation and long-term consolidation of information.