Tunable oscillations in the Purkinje neuron.

  title={Tunable oscillations in the Purkinje neuron.},
  author={Ze’ev R. Abrams and Ajithkumar Warrier and Yuan Wang and Dirk Trauner and Xiang Zhang},
  journal={Physical review. E, Statistical, nonlinear, and soft matter physics},
  volume={85 4 Pt 1},
In this paper, we experimentally study the dynamics of slow oscillations in Purkinje neurons in vitro, and derive a strong association with a forced parametric oscillator model. We observed the precise rhythmicity of these oscillations in Purkinje neurons, as well as a dynamic tunability of this oscillation using a photoswitchable compound. We found that this slow oscillation can be induced in every Purkinje neuron measured, having periods ranging between 10 and 25 s. Starting from a Hodgkin… 

Figures from this paper

Temporal integration and 1/f power scaling in a circuit model of cerebellar interneurons.

Stellate and basket cells in cerebellar cortex, and interneuron circuits in general, may not only provide fast inhibition to principal cells but also act as temporal integrators that build a very short-term memory.

Power Spectral Density Analysis of Purkinje Cell Tonic and Burst Firing Patterns From a Rat Model of Ataxia and Riluzole Treated

Spectral analysis of PCs firing in control, 3-acetylpyridine, neurotoxin agent, treated alone and riluzole plus 3-AP treated were investigated to determine changes in the firing properties and alterations in the power spectral density were found.

Photoswitchable Ion Channels and Receptors

The design, operation, and applications of the available photoswitches, with special emphasis on ligand- and voltage-gated channels, are described.

Theta-Frequency Resonance at the Cerebellum Input Stage Improves Spike Timing on the Millisecond Time-Scale

It is shown that, at the cerebellum input stage, the granular layer (GRL) generates its maximum response at 5–7 Hz both in vivo following tactile sensory stimulation of the whisker pad and in acute slices following mossy fiber bundle stimulation.



Dynamical Systems in Neuroscience: The Geometry of Excitability and Bursting

This book explains the relationship of electrophysiology, nonlinear dynamics, and the computational properties of neurons, with each concept presented in terms of both neuroscience and mathematics and illustrated using geometrical intuition, providing a link between the two disciplines.

J. S. Albus, Math. Biosci

  • J. S. Albus, Math. Biosci
  • 1971

Neuroscience 細胞死:最近の知見

I and J

Neural mechanisms of learning and control

Recent advances in motor control and learning are introduced, namely, the role of the basal ganglia in acquisition of goal-directed behaviors, learning of internal models by the cerebellum, and decomposition of complex tasks by the competition of predictive models.

Cell Calcium

    A quantitative description of membrane current and its application to conduction and excitation in nerve.

    This article concludes a series of papers concerned with the flow of electric current through the surface membrane of a giant nerve fibre by putting them into mathematical form and showing that they will account for conduction and excitation in quantitative terms.

    LY339434, a GluR5 kainate receptor agonist

    Cerebellar circuitry as a neuronal machine