Tunable Probes with Direct Fluorescence Signals for the Constitutive and Immunoproteasome.


Electrophiles are commonly used for the inhibition of proteases. Notably, inhibitors of the proteasome, a central determinant of cellular survival and a target of several FDA-approved drugs, are mainly characterized by the reactivity of their electrophilic head groups. We aimed to tune the inhibitory strength of peptidic sulfonate esters by varying the… (More)
DOI: 10.1002/anie.201605753


3 Figures and Tables

Slides referencing similar topics