Tunable Probes with Direct Fluorescence Signals for the Constitutive and Immunoproteasome.

Abstract

Electrophiles are commonly used for the inhibition of proteases. Notably, inhibitors of the proteasome, a central determinant of cellular survival and a target of several FDA-approved drugs, are mainly characterized by the reactivity of their electrophilic head groups. We aimed to tune the inhibitory strength of peptidic sulfonate esters by varying the… (More)
DOI: 10.1002/anie.201605753

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