Tunable DNA cleavage by intercalating peptidoconjugates.


The properties of a novel family of peptide-based DNA-cleavage agents are described. Examination of the DNA-cleavage activities of a systematic series of peptide-intercalator conjugates revealed trends that show a strong dependence on peptide sequence. Conjugates differing by a single residue displayed reactivities that varied over a wide range. The… (More)


Cite this paper

@article{Mahon2006TunableDC, title={Tunable DNA cleavage by intercalating peptidoconjugates.}, author={Kerry P Mahon and Marc D Roy and Jay R Carreon and Erin G Prestwich and Jessica L Rouge and Stephanie Shin and Shana O. Kelley}, journal={Chembiochem : a European journal of chemical biology}, year={2006}, volume={7 5}, pages={766-73} }