Tumultuous relationship between the human immunodeficiency virus type 1 viral infectivity factor (Vif) and the human APOBEC-3G and APOBEC-3F restriction factors.

@article{Henriet2009TumultuousRB,
  title={Tumultuous relationship between the human immunodeficiency virus type 1 viral infectivity factor (Vif) and the human APOBEC-3G and APOBEC-3F restriction factors.},
  author={Simon Henriet and Ga{\"e}lle Mercenne and Serena Bernacchi and Jean-Christophe Paillart and Roland Marquet},
  journal={Microbiology and molecular biology reviews : MMBR},
  year={2009},
  volume={73 2},
  pages={211-32}
}
The viral infectivity factor (Vif) is dispensable for human immunodeficiency virus type 1 (HIV-1) replication in so-called permissive cells but is required for replication in nonpermissive cell lines and for pathogenesis. Virions produced in the absence of Vif have an aberrant morphology and an unstable core and are unable to complete reverse transcription. Recent studies demonstrated that human APOBEC-3G (hA3G) and APOBEC-3F (hA3F), which are selectively expressed in nonpermissive cells… CONTINUE READING

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