Tumours can adapt to anti-angiogenic therapy depending on the stromal context: lessons from endothelial cell biology.

@article{Kempen2006TumoursCA,
  title={Tumours can adapt to anti-angiogenic therapy depending on the stromal context: lessons from endothelial cell biology.},
  author={L{\'e}on C van Kempen and William P J Leenders},
  journal={European journal of cell biology},
  year={2006},
  volume={85 2},
  pages={
          61-8
        }
}
It has long been recognized that interference with the blood supply of a tumour is an effective way to halt tumour progression, and even induce tumour regression. This can be accomplished by anti-angiogenic treatment which prevents the formation of a tumour neovasculature, or anti-vascular treatment, which aims at destruction of existent tumour vessels. The latter has received relatively little attention because there is a lack of specific tumour-endothelial markers. Instead, the current… CONTINUE READING

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