Tumourigenic canine osteosarcoma cell lines associated with frizzled‐6 up‐regulation and enhanced side population cell frequency

@article{deSRodrigues2017TumourigenicCO,
  title={Tumourigenic canine osteosarcoma cell lines associated with frizzled‐6 up‐regulation and enhanced side population cell frequency},
  author={Lucas Campos de S{\'a} Rodrigues and Katie E Holmes and Victoria Thompson and Michael A. Newton and Timothy J. Stein},
  journal={Veterinary and Comparative Oncology},
  year={2017},
  volume={15},
  pages={78–93}
}
An increased serum alkaline phosphatase concentration is known to be associated with a negative prognosis in canine and human osteosarcoma. To expand upon previous studies regarding the biological relevance of increased serum alkaline phosphatase as a negative prognostic factor, xenogeneic heterotopic transplants were performed using six canine primary osteosarcoma cell lines generated from patients with differing serum alkaline phosphatase concentrations (three normal and three increased… 
3 Citations
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