Tumour suppressor genes in the pathogenesis of human pituitary tumours.

  title={Tumour suppressor genes in the pathogenesis of human pituitary tumours.},
  author={Richard N. Clayton and Mike Boggild and Andrew S. Bates and John E. Bicknell and David J. W. Simpson and William E Farrell},
  journal={Hormone research},
  volume={47 4-6},
Abnormal cell proliferation is controlled by opposing actions of oncogene products (stimulatory) and tumour suppressor gene (TSG) products (inhibitory). The former are dominantly acting, i.e. only one copy needed for tumorigenesis, whilst for TSG both copies of the gene must be inactivated so these are recessive at a cellular level. For anterior pituitary tumours only one oncogene (Gsp) has been identified in a variable proportion (4-40%) of a single tumour subtype (somatotrophinomas… CONTINUE READING
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