Tumour suppression by p53: the importance of apoptosis and cellular senescence.

@article{Zuckerman2009TumourSB,
  title={Tumour suppression by p53: the importance of apoptosis and cellular senescence.},
  author={Valentina Zuckerman and Kamil Wolyniec and Ronit Vogt Sionov and Sue Haupt and Ygal Haupt},
  journal={The Journal of pathology},
  year={2009},
  volume={219 1},
  pages={3-15}
}
p53 is regarded as a central player in tumour suppression, as it controls programmed cell death (apoptosis) as well as cellular senescence. While apoptosis eliminates cells at high risk for oncogenic transformation, senescence acts as a barrier to tumourigenesis by imposing irreversible cell cycle arrest. p53 can act directly or indirectly at multiple levels of the tumour suppression network by invoking a myriad of mechanisms. p53 induces the extrinsic and intrinsic apoptotic pathways at… CONTINUE READING