Tumour-stromal interactions in acid-mediated invasion: a mathematical model.

@article{Martin2010TumourstromalII,
  title={Tumour-stromal interactions in acid-mediated invasion: a mathematical model.},
  author={Natasha Kaleta Martin and Eamonn A. Gaffney and Robert A. Gatenby and Philip K. Maini},
  journal={Journal of theoretical biology},
  year={2010},
  volume={267 3},
  pages={461-70}
}
It is well established that the tumour microenvironment can both promote and suppress tumour growth and invasion, however, most mathematical models of invasion view the normal tissue as inhibiting tumour progression via immune modulation or spatial constraint. In particular, the production of acid by tumour cells and the subsequent creation of a low… CONTINUE READING